Novel Peptide-Modified Gemini Surfactants as Gene Carriers: Structure Activity Relationship, Physiochemical Characterizations and Mass Spectrometric Dissociation Behaviour
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منابع مشابه
Comparative effect of cationic gemini surfactant and its monomeric counterpart on the conformational stability and activity of lysozyme
Protein interactions with surfactants are dependent on their physiochemical properties. The effect of cationic gemini surfactant hexanediyl-a,u-bis-(N-(2-hydroxyethyl)-N-methylhexadecylammonium dibromide) on the stability and activity of hen egg white lysozyme was compared with its monomeric counterpart N-(2-hyroxyethyl)-N,N-dimethylhexadecylammonium bromide at pre and post micellar concentrati...
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PURPOSE Cationic gemini surfactants have been studied as non-viral vectors for gene therapy. Clinical applications of cationic lipid/DNA lipoplexes are restricted by their instability in aqueous formulations. In this work, we investigated the influence of lyophilization on the essential physiochemical properties and in vitro transfection of gemini surfactant-lipoplexes. Additionally, we evaluat...
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CMC (critical micelle concentration) is lowest concentration when micelle was created in aqueous solution of surfactant. In this study, we collected CMC data to develop the QSPR model of gemini surfactants from literatures. Gemini surfactants are composed of two monomeric surfactant molecules linked by a spacer chain. Gemini surfactants can self-assemble at concentrations almost a hundred-fold ...
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A novel quaternary ammonium-based cationic gemini surfactant (S6) having 1,6 di-bromo hexane as a spacer, have been used and its interaction with insulin in aqueous solution (pH, 7.40) was investigated by several methods including fluorescence spectroscopy, UV-Vis spectroscopy, circular dichroism, dynamic light scattering, ζ-potential measurements, conductivity and transmission electron microsc...
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Gemini surfactants and their interactions with proteins have gained considerable scientific interest, especially when amyloidogenic proteins are taken into account. In this work, the influence of two selected dicationic (gemini) surfactants (3,3'-[1,8-(2,7-dioxaoctane)]bis(1-dodecylimidazolium) chloride and 3,3'-[1,12-(2,11-dioxadodecane)]bis(1-dodecylimidazolium) chloride) on two model protein...
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